Gelita, the German headquartered supplier of peptides and gelatin solutions for the nutritional sector, will introduce its latest innovations, including its softgel controlled release portfolio featuring DELASOL for enteric softgels, RAPISOL for rapid release, and RXL Ultra to combat crosslinking, which can cause softgels to harden and affect gastrointestinal dissolution and release rates. At a presentation during the event, experts from Gelita will discuss overcoming crosslinking using plant-based ingredients. The company will also present EASYSEAL, a solution to reduce leaks in softgel production.

As demand for sterile injectable fill/finish services continues to grow, Steriline will present its latest robotic vial filling and capping machine. By using robotics to handle high-quality vial filling and capping operations, the automated system promises precision, reducing contamination risks, and increasing production efficiency.

M&M Packaging will discuss key market trends, challenges, and solutions in pharmaceutical packaging at CPHI Milan 2024. With growing demands for sustainable materials, compliance with global regulations, and innovative designs for drug delivery, M&M aims to present the latest advances that meet industry needs. Their focus will be on improving safety, usability, and sustainability in packaging to keep pace with the evolving pharmaceutical landscape. 

Sanner Group, the healthcare packaging and medical device CDMO, has announced it has acquired Gilero, a medical device designer, developer, and contract manufacturer headquartered in Durham, North Carolina. The acquisition helps position Sanner as a leading provider of end-to-end services across drug delivery, diagnostics, and MedTech device sectors. Gilero brings with it 130 engineers based across facilities in the U.S., Mexico, and Ireland.

Plastic packaging manufacturer Berry Global will unveil its latest patient-centric drug delivery systems in Milan, focusing on enhancing ease of use and safety for patients. Key innovations from the company include cutting-edge inhalers, injectors, and other sustainable packaging solutions tailored to pharmaceutical needs. The company will offer attendees the opportunity to explore its expertise in creating customizable solutions that improve patient outcomes and reduce environmental impact.

Serán BioScience announced that it had completed an expansion to add eight state-of-the art process manufacturing suites at its facility in Bend, Oregon, adding around 130% more CGMP clinical manufacturing capacity. The suites will provide increased flexible capacity for late-stage clinical trial supply for small-molecule drugs.

Biotech firm eGenesis has raised $191 mn to advance its genetically modified pig kidney transplant program, utilizing its gene-editing technology that makes pig organs more compatible with human immune systems. The raised funds will be used to support clinical trials for the company's lead candidate - EGEN-2784 - a pig kidney engineered to be human-compatible after successful, though short-lived, human transplant earlier in 2024.

Eli Lilly has entered a major collaboration with Swiss biotech Haya Therapeutics to develop innovative drugs targeting metabolic conditions like obesity. The partnership, which could be as valuable as $1 bn, focuses on exploring the "dark genome" — the 98% of human DNA that does not code for proteins but plays critical regulatory roles.

Bayer has unveiled a new ecosystem aimed at supporting healthy aging, responding to growing consumer interest in wellness and longevity, by offering a range of products and services designed to promote better health outcomes as people age.

Amgen is advancing its next-generation obesity drug, MariTide, into a Phase 3 clinical program aimed at addressing obesity in conjunction with other weight-related conditions such as heart, liver, and kidney diseases. The injectable therapy, which activates the GLP-1 receptor while blocking the GIP receptor, demonstrated a 14.5% reduction in body weight during Phase 1 trials.

The first pills date back to roughly 1,500 BC, and whilst the pharmaceutical landscape continues to evolve, drug delivery via oral solid dosage (OSD) remains a dominant form due to the ease with which tablets are administered, patients’ familiarity with the dose form, and efficient manufacturing techniques.

Lonza has completed an expansion of its microbial manufacturing facility at Visp, Switzerland, to address the growing demand for microbial manufacturing - driven by the rise of smaller, more complex molecules in the biotech pipeline - and boost its capacity to meet the increasing demand for microbial-based biologics.

The UK government has introduced legislation to ban xylazine and 21 other dangerous substances, including six highly potent synthetic opioids. Xylazine, a veterinary sedative also known as "tranq," is used illicitly to extend opioid doses and has caused severe health issues and overdose deaths. The new law categorizes xylazine as a Class C drug and other potent opioids as Class A, imposing strict penalties for production and distribution.

In a deal worth up to $409 mn, Eli Lilly has partnered with Genetic Leap to accelerate RNA-targeted drug discovery using AI. The collaboration will focus on developing oligonucleotide therapies for key diseases; enhancing Lilly’s growing expertise in RNA-based treatments.

Superluminal Medicines has closed a $120 mn Series-A funding round to accelerate its drug discovery efforts focused on G protein-coupled receptor (GPCR) targets, a key class of membrane proteins involved in many diseases. The company employs a combination of generative biology, chemistry, and machine learning to rapidly develop candidate-ready compounds, focusing on membrane receptors that are often challenging to target.

Bora Pharmaceuticals has formed a strategic alliance with Tanvex BioPharma to combine their respective strengths in biologics development and global manufacturing, leveraging Tanvex's U.S. FDA-licensed facility and biosimilar expertise with Bora's extensive CDMO capabilities, which include 10 global manufacturing sites.

Lotte Group, the South Korean conglomerate, plans to restructure its bio division by focusing on its profitable CDMO services business and shutting down loss-making Lotte Healthcare. The restructuring includes discontinuing its direct-to-consumer genetic testing business and transferring its health-functional food division to Lotte Wellfood.

CoreRx, Societal CDMO, and Bend Bioscience have announced a merger under the Bend Bioscience brand to create, they say, a unified, world-class CDMO combining the expertise and capabilities of the three companies to enhance their service offerings in pharmaceutical development and manufacturing.

After a challenging few years, the biotech sector is experiencing a bifurcation in funding. While early-stage companies struggle to secure financing, clinical-stage biotechs and those in ‘hot’ therapeutic areas are thriving. This “winner-takes-all” environment is driven by both VCs and big pharma companies, which are increasingly drawn to assets closer to market.

Hong Kong biopharmaceutical company, Everest Medicines, has initiated an investigator-initiated clinical trial (IIT) to explore a personalized mRNA cancer vaccine targeting specific tumor mutations. The study aims to evaluate the vaccine's safety, immunogenicity, and preliminary efficacy, and represents a significant step in the development of mRNA-based therapies for cancer treatment.